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Research and clinical trials

Current research studies

Minimally Invasive Surgery +rTPA for Intercerebral Hemorrhage Evacuation (“MISTIE III”)
William Broaddus, M.D./Johns Hopkins University
9/17/2015 – 7/31/2018

Determining the Optimal Dosing Schedule for the Commercialization of Miberfradil in Front-Line Glioblastoma
William Broaddus, M.D./Cavion, LLC
5/5/2014 – 12/31/2016

Deep Brain Stimulation of the Nucleus Basalis of Meynert to Improve Cognitive Function in Parkinson's Disease Dementia
Kathryn Holloway, M.D./Michael J. Fox Foundation
8/2/2016 – 2/2/2017

Framing Eighteen Coils in Cerebral Aneurysms Trial (“FEAT”)
John Reavey-Cantwell, M.D./Vanderbilt University
10/30/2012 – 10/2017

Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms with the Neuroform Atlas Stent (“ATLAS”)
John Reavey-Cantwell,  M.D./Stryker Biotech
9/4/2015 – 9/3/2017

Conversion of Clinical Data from the NABISH I and II into FITBIR
Emmy Miller, Ph.D./DOD
7/20/2016 – 12/29/2016

International Traumatic Brain Injury … TRACK TBI
Bruce Mathern, MD./University of California, San Francisco
8/1/2012 – 8/31/2017

Targeting NLRP3 Inflammasomes to Treat Traumatic Brain Injury with a Novel Pharmacological Inhibitor
Dong Sun, Ph.D./Commonwealth Health Research Board
7/1/2015 – 6/30/2017

Development of Novel NLRP3 Inhibitors Toward Alzheimer’s Disease
Dong Sun, Ph.D./Alzheimer’s Foundation
8/18/2015 – 2/17/2017

Combination of hiPSCs and Bioengineering to Repair Injured Pediatric Brain
Dong Sun, Ph.D./NIH
6/1/2016 – 5/31/2021

VCU Department of Neurosurgery research news

Collaborative research between VCU Neurosurgery and VCU’s biomedical engineering department

Ann Ritter, M.D., is a co-investigator with the lab of Rene Olivares-Navarrete, D.D.S., Ph.D., in the biomedical engineering department at Virginia Commonwealth University. The main aim of the studies is to understand normal suture formation and non-syndromic craniosynostosis. The team has developed a model consisting of micro-CT analysis followed by gene expression analysis in normal suture, as well as in the open, fusing and fused areas of the sagittal suture. The samples for these studies are obtained from many ages of normal sutural closure and abnormal samples obtained from minimally invasive surgeries to correct this process.

The collaboration between the Olivares-Navarrete lab in the biomedical engineering department and the pediatric neurosurgeons has raised additional lines of inquiry. Further studies may include the role of dura matter (the covering around the brain) in normal and abnormal suture development, a tissue engineering model of normal and abnormal suture fusion, as well as possible target treatments.

Published: Minimizing transfusion requirements for children undergoing craniosynostosis repair: The CHoR protocol

Vega RA, Lyon C, Kierce JF, Tye GW, Ritter AM, Rhodes JL. J Neurosurg Pediatr. 2014 Aug;14(2):190-5. doi: 10.3171/2014.4.PEDS13449. Epub 2014 May 30.

Read Minimizing transfusion requirements for childen undergoing craniosynostosis repair: The CHoR protocol

Published: Hypophosphatemic rickets and craniosynostosis: A multicenter case series

Vega RA, Opalak C, Harshbarger RJ, Fearon JA, Ritter AM, Collins JJ, Rhodes JL.
J Neurosurg Pediatr. 2016 Jun;17(6):694-700. doi: 10.3171/2015.10.PEDS15273. Epub 2016 Jan 29.

Read Hypophosphaemic rickets and craniosynostosis: A multicenter case series

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