Minimally Invasive Surgery +rTPA for Intercerebral Hemorrhage Evacuation (“MISTIE III”)
William Broaddus, M.D./Johns Hopkins University
9/17/2015 – 7/31/2018
Determining the Optimal Dosing Schedule for the Commercialization of Miberfradil in Front-Line Glioblastoma
William Broaddus, M.D./Cavion, LLC
5/5/2014 – 12/31/2016
Deep Brain Stimulation of the Nucleus Basalis of Meynert to Improve Cognitive Function in Parkinson's Disease Dementia
Kathryn Holloway, M.D./Michael J. Fox Foundation
8/2/2016 – 2/2/2017
Framing Eighteen Coils in Cerebral Aneurysms Trial (“FEAT”)
John Reavey-Cantwell, M.D./Vanderbilt University
10/30/2012 – 10/2017
Safety and Effectiveness of the Treatment of Wide Neck, Saccular Intracranial Aneurysms with the Neuroform Atlas Stent (“ATLAS”)
John Reavey-Cantwell, M.D./Stryker Biotech
9/4/2015 – 9/3/2017
Conversion of Clinical Data from the NABISH I and II into FITBIR
Emmy Miller, Ph.D./DOD
7/20/2016 – 12/29/2016
International Traumatic Brain Injury … TRACK TBI
Bruce Mathern, MD./University of California, San Francisco
8/1/2012 – 8/31/2017
Targeting NLRP3 Inflammasomes to Treat Traumatic Brain Injury with a Novel Pharmacological Inhibitor
Dong Sun, Ph.D./Commonwealth Health Research Board
7/1/2015 – 6/30/2017
Development of Novel NLRP3 Inhibitors Toward Alzheimer’s Disease
Dong Sun, Ph.D./Alzheimer’s Foundation
8/18/2015 – 2/17/2017
Combination of hiPSCs and Bioengineering to Repair Injured Pediatric Brain
Dong Sun, Ph.D./NIH
6/1/2016 – 5/31/2021
Ann Ritter, M.D., is a co-investigator with the lab of Rene Olivares-Navarrete, D.D.S., Ph.D., in the biomedical engineering department at Virginia Commonwealth University. The main aim of the studies is to understand normal suture formation and non-syndromic craniosynostosis. The team has developed a model consisting of micro-CT analysis followed by gene expression analysis in normal suture, as well as in the open, fusing and fused areas of the sagittal suture. The samples for these studies are obtained from many ages of normal sutural closure and abnormal samples obtained from minimally invasive surgeries to correct this process.
The collaboration between the Olivares-Navarrete lab in the biomedical engineering department and the pediatric neurosurgeons has raised additional lines of inquiry. Further studies may include the role of dura matter (the covering around the brain) in normal and abnormal suture development, a tissue engineering model of normal and abnormal suture fusion, as well as possible target treatments.
Vega RA, Lyon C, Kierce JF, Tye GW, Ritter AM, Rhodes JL. J Neurosurg Pediatr. 2014 Aug;14(2):190-5. doi: 10.3171/2014.4.PEDS13449. Epub 2014 May 30.
Vega RA, Opalak C, Harshbarger RJ, Fearon JA, Ritter AM, Collins JJ, Rhodes JL.
J Neurosurg Pediatr. 2016 Jun;17(6):694-700. doi: 10.3171/2015.10.PEDS15273. Epub 2016 Jan 29.
Find out about participating in study opportunities through VCU’s Department of Neurosurgery.
Find out about participating in clinical trials currently being conducted by VCU’s Department of Neurosurgery.